From bits
to atoms

CinThesis is the state of the art bacteriocin discovery platform.

What is CinThesis

Find the bacteriocins other tools miss

CinThesis analyzes genomic sequence data and identifies bacteriocins (natural antimicrobial peptides) along with what they target and how they work. Unlike tools that rely on sequence similarity to known families, it reasons from biological first principles. That means novel candidates that existing methods simply cannot see.

Why it matters

Antimicrobial resistance is accelerating. Bacteriocins are one of the most promising untapped compound classes in nature. Discovery has always been the bottleneck. CinThesis is built to change that.

Six Dimensions, One Answer

Every sequence is evaluated across six independent analytical pipelines. Convergent evidence across all six, not any single signal, drives the classification.

1

Physicochemical Properties

Charge, amphipathicity, hydrophobicity: the biophysical fingerprint of antimicrobial function

2

Secondary Structure

Helical and sheet propensity, conformational fit to known antimicrobial mechanisms

3

Domain Architecture

Conserved functional domains annotated against InterPro

4

Evolutionary Context

Phylogenetic relationships to characterized bacteriocin families

5

Sequence Embeddings

Transformer-based (ProteinBERT) representations capturing deep biological patterns

6

3D Structure Prediction

AlphaFold-powered structure revealing mechanism-defining topology

Proteosemantic Intelligence

LLMs synthesize all six pipelines into coherent biological narratives, translating raw signals into understanding you can act on.

Accounts for ~75% of CinThesis's predictive signal.

Four Classifications. One Complete Dossier.

1

Canonical Bacteriocins

High-confidence antimicrobial peptides consistent with characterized bacteriocin families.

2

Putative Bacteriocins

Novel candidates with evidence of antimicrobial function but limited homology to known families. These are the discoveries existing tools miss.

3

NBAPs

Non-Bacteriocin Antimicrobial Proteins including Type VI secretion systems and contact-dependent inhibition mechanisms.

4

Non-Antimicrobial

Clearly separated from candidates worth pursuing, with full classification transparency.

Every Sequence Gets a Complete Biological Report

Classification with model scores and confidence

Physicochemical profile across 1,200+ molecular properties

AlphaFold 3D structure visualization

Domain annotations, phylogenetic tree, topology diagram

Narrative analysis grounded in scientific literature

Why Researchers Choose CinThesis

Prioritize, don't screen blindly

Know which candidates are worth pursuing, and why, before running a single assay.

Find what's never been found

First-principles reasoning surfaces candidates from novel compound classes that homology-based tools cannot reach.

See the full picture

Beyond bacteriocins, CinThesis reveals all antimicrobial mechanisms encoded in an organism: T6SS, CDI, and more.

Design better experiments

Predicted structure, mechanism class, and operon organization give you the context to validate efficiently.

Ready to start discovering?

Join the waitlist or download the white paper to learn more.